Limited cells from donors, expensive media?

Using the Breez Microbioreactor for T Cell Culture

The Breez 2 mL microbioreactor for cell therapy development

Presentation Video Title:


Cell Therapy Process Development with a 2 mL Continuous Perfusion Bioreactor

With several CAR-T cell immunotherapy products currently marketed for the treatment of hematological cancers, there are increasing efforts to develop better technologies and processes for cell therapies to improve efficacy, reduce variability, and decrease costs. Ways to optimize cell activation, transduction, and expansion for cell-based treatments are improving, but major challenges still exist in experiment reproducibility and robustness during process development. Variability of donor and patient-derived material can confound experiment results. Reagent cost, scarce bench space, and busy scientists can limit the number of experiments possible. Therefore, process development experiments are typically done in milliliter-sized static plates with minimal environmental control and can lead to sub-optimal outcomes.

Watch the video presentation now: Cell Therapy Process Development with a 2 mL Continuous Perfusion Bioreactor

The Breez™ perfusion microbioreactor can support >400M cells in only a 2mL working volume. This fully closed single-use perfusion bioreactor operates outside of a biosafety cabinet and replicates benchscale perfusion processes at industrially relevant cell densities. The use of integrated microfluidics reduces labor, bench space, and materials, enabling a single donor to be used in many bioreactor experiments.


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